In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids
| Autor: | Luciana Giardino, C. Bettelli, Laura Calzà |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Thyroid Hormones Retinoic acid Subventricular zone Antineoplastic Agents Nerve Tissue Proteins Tretinoin Biology Nestin Rats Sprague-Dawley chemistry.chemical_compound Intermediate Filament Proteins Internal medicine Precursor cell Lateral Ventricles medicine Animals Neural Cell Adhesion Molecules Cell growth Cell adhesion molecule General Neuroscience Cell biology Rats Endocrinology medicine.anatomical_structure Ki-67 Antigen nervous system Nuclear receptor chemistry Biomarkers Hormone |
| Zdroj: | Neuroscience letters. 295(1-2) |
| ISSN: | 0304-3940 |
| Popis: | The mature central nervous system contains precursor cells in the subventricular zone of the lateral ventricle. In this study we examined the possibility to affect fate of precursor cells through exogenous manipulations. The results indicate that administration of thyroid hormone and retinoic acid increases the expression of Ki67, a nuclear antigen associated with cell proliferation, and of nestin, a marker protein for precursor cells in the subventricular zone of adult male rats. Moreover, retinoic acid increases polysialated-neural cell adhesion molecules (PSA-NCAM)-immunoreactivity. These data suggest that nuclear receptor ligands are potential candidates for fate determination of precursor cells in the subventricular zone also in the adult brain. |
| Databáze: | OpenAIRE |
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