Cerebral Hemiatrophy – Correlation of Human with Animal Experimental Data
Autor: | Ronald E. Myers, G M de Courten-Myers, T. I. Mandybur, L Ford |
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Rok vydání: | 1988 |
Předmět: |
Male
medicine.medical_specialty Ischemia Brain damage Fetal Hypoxia Cerebral palsy Pregnancy Internal medicine Intensive care medicine Hemiatrophy Animals Humans Asphyxia business.industry Brain General Medicine Middle Aged medicine.disease Macaca mulatta Perinatal asphyxia Surgery Disease Models Animal Microscopy Electron Cerebral blood flow Pediatrics Perinatology and Child Health Cardiology Female Neurology (clinical) Atrophy medicine.symptom business |
Zdroj: | Pediatric Neurosurgery. 14:114-119 |
ISSN: | 1423-0305 1016-2291 |
Popis: | We report the neuropathologic findings in a 63-year-old white male with a history of birth asphyxia, cerebral palsy, seizures and mild mental retardation in conjunction with similar brain pathologic findings in animal models of perinatal asphyxia. The human case showed a left cerebral hemispheric hemiatrophy associated with an extensive ulegyria involving all cerebral lobes on that side and a single microscopic focus of cortical atrophy in the right hemisphere. Among a large number of experimental perinatal asphyctic exposures only an occasional animal, like the human case described, showed unilateral hemispheric injury with softening and necrosis if examined early and ulegyria with hemispheric hemiatrophy if examined late. The present paper suggests that perinatal asphyxia under specific pathophysiologic conditions may cause unilateral brain injury. Our experimental studies suggest the specific condition of perinatal asphyxia potentially causing unilateral or asymmetrical brain damage is marked hypoxemia combined with substantial reductions in blood pressure but without circulatory collapse. Given these conditions, the asymmetry of the brain damage likely reflects fetal head position within the gravitational field relative to the heart. With disturbed cerebral blood flow autoregulation from asphyxia, the gravitational field likely accentuates the ischemia of those brain areas most elevated above the level of the heart. Thus, we postulate head position may play a pivotal role in defining brain regions that are damaged in hypotensive perinatal asphyxia. This interpretation may affect the intensive care of hypoxemic, hypotensive newborns aimed at minimizing the risk of brain damage. |
Databáze: | OpenAIRE |
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