Tissue‐Adaptive Materials with Independently Regulated Modulus and Transition Temperature
Autor: | Farahnaz Fahimipour, Daixuan Zhang, Egor A. Bersenev, Erfan Dashtimoghadam, Sergei S. Sheiko, Mohammad Vatankhah-Varnoosfaderani, Dimitri A. Ivanov, Qiaoxi Li, Xiaobo Hu |
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Přispěvatelé: | University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Moscow Institute of Physics and Technology [Moscow] (MIPT), the Russian Academy of Sciences [Moscow, Russia] (RAS), Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Lomonosov Moscow State University (MSU), Ivanov, Dimitri, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Materials science
Biocompatibility poly(valerolactone) Modulus 02 engineering and technology network architecture 010402 general chemistry 01 natural sciences Elastic Modulus Materials Testing [CHIM] Chemical Sciences Side chain Transition Temperature stimuli-responsive materials [CHIM]Chemical Sciences General Materials Science Composite material Softening chemistry.chemical_classification [CHIM.MATE] Chemical Sciences/Material chemistry Mechanical Engineering Transition temperature Drop (liquid) Polymer [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences bottlebrush elastomers Smart Materials chemistry Mechanics of Materials 0210 nano-technology controlled release |
Zdroj: | Advanced Materials Advanced Materials, Wiley-VCH Verlag, 2020, 32 (50), pp.2005314. ⟨10.1002/adma.202005314⟩ Advanced Materials, 2020, 32 (50), pp.2005314. ⟨10.1002/adma.202005314⟩ |
ISSN: | 0935-9648 1521-4095 |
Popis: | International audience; The ability of living species to transition between rigid and flexible shapes represents one of their survival mechanisms, which has been adopted by various human technologies. Such transition is especially desired in medical devices as rigidity facilitates the implantation process, while flexibility and softness favor biocompatibility with surrounding tissue. Traditional thermoplastics cannot match soft tissue mechanics, while gels leach into the body and alter their properties over time. Here, a single-component system with an unprecedented drop of Young's modulus by up to six orders of magnitude from the GPa to kPa level at a controlled temperature within 28-43 °C is demonstrated. This approach is based on brush-like polymer networks with crystallizable side chains, e.g., poly(valerolactone), affording independent control of melting temperature and Young's modulus by concurrently altering side chain length and crosslink density. Softening down to the tissue level at the physiological temperature allows the design of tissue-adaptive implants that can be inserted as rigid devices followed by matching the surrounding tissue mechanics at body temperature. This transition also enables thermally triggered release of embedded drugs for anti-inflammatory treatment. |
Databáze: | OpenAIRE |
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