Incidence, Clinical Characteristics, Long-Term Course, and Comparison of Progressive and Nonprogressive Cases of Aphthous-Type Crohn's Disease: A Single-Center Cohort Study
| Autor: | Takahiro Beppu, Kozue Tsurumi, Takashi Nagahama, Satoshi Ishikawa, Shoko Fujiwara, Noritaka Takatsu, Yasuhiro Takaki, Toshiyuki Matsui, Kenshi Yao, Yu Matsushima, Yuki Okado, Akinori Iwashita, Yoichiro Ono, Yuho Sato, Naoyuki Yoshizawa, Yutaka Yano, Takashi Hisabe, Fumihito Hirai |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Disease Single Center Gastroenterology Cohort Studies Young Adult Crohn Disease Japan Internal medicine medicine Humans Child Crohn's disease business.industry Incidence Incidence (epidemiology) medicine.disease digestive system diseases stomatognathic diseases Disease Progression Female Early phase business Cohort study |
| Zdroj: | Digestion. 87:262-268 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | Background/Aims: In Japan, aphthous-type Crohn's disease (type A CD) is thought to represent an early phase of Crohn's disease (CD), and diagnosis of type A CD is possible in the diagnostic criteria for CD in Japan. However, the details of type A CD are not well understood. Methods: Subjects comprised 649 CD patients diagnosed between 1985 and 2011. The incidence of type A CD over time was clarified in two periods (1985-2004 and 2005-2011). The course of type A CD was also investigated, and cases that did and did not progress to typical CD were compared. Results: No significant difference was seen in the incidence of type A CD between the two periods (5.2 vs. 8.5%, p = 0.125). Type A CD patients followed at our hospital progressed to typical CD at a rate of 59.3%. In comparing progressive and nonprogressive cases, the frequency of large, densely distributed aphthous lesions in the small intestine was higher among progressive cases (p = 0.018). Conclusion: Type A CD is an early phase of CD, and CD diagnostic criteria including early cases are valid in Japan. |
| Databáze: | OpenAIRE |
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