Late Administration of Surfactant May Increase the Risk of Patent Ductus Arteriosus
| Autor: | Sarkhan Elbayiyev, Gülsüm Kadıoğlu Şimşek, James Webbe, Fuat Emre Canpolat, H Gözde Kanmaz Kutman, Nazmiye Bengü Karaçağlar, Mehmet Büyüktiryaki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities surfactant 030204 cardiovascular system & hematology Pediatrics preterm infant 03 medical and health sciences patent ductus arteriosus 0302 clinical medicine Pulmonary surfactant 030225 pediatrics Ductus arteriosus medicine cardiovascular diseases early rescue business.industry lcsh:RJ1-570 Gestational age Retrospective cohort study lcsh:Pediatrics Brief Research Report respiratory distress syndrome medicine.anatomical_structure Increased risk Anesthesia Pediatrics Perinatology and Child Health cardiovascular system Population study business Patent ductus arteriosis |
| Zdroj: | Frontiers in Pediatrics, Vol 8 (2020) Frontiers in Pediatrics |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2020.00130/full |
| Popis: | Introduction: Early rescue surfactant is the most effective way of administering surfactant but many infants still receive surfactant later. Our aim was to explore the association between timing of surfactant administration and the development of patent ductus arteriosus and other neonatal morbidities. Materials and method: This retrospective study analyzed 819 preterm infants under 30 weeks of gestational age and under 1,500 g. Results: Five hundred and ninety three infants received surfactant during the study period, of these 365 received it within 2 h of life (early group) and 228 received it after two h (late group). Patent ductus arteriosus was detected in 175 (48%) of the early group and 168 (74%) of the late group, p = 0.001. Multinominal logistic regression analysis demonstrated that receiving surfactant after 2 h of life has a OR 3.5 (2.2-5.64 95 % CI) and a p-value of 0.001 for developing patent ductus arteriosus. Conclusion: In this study population we observed that late surfactant administration is associated with increased risk of patent ductus arteriosus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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