Circulating inflammatory markers impact cognitive functions in bipolar depression
| Autor: | Mario Gennaio Mazza, Elena Manfredi, Cristina Lorenzi, Francesco Benedetti, Sara Poletti, Cristina Colombo, Federico Calesella, Benedetta Vai, Raffaella Zanardi |
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| Přispěvatelé: | Poletti, S., Mazza, M. G., Calesella, F., Vai, B., Lorenzi, C., Manfredi, E., Colombo, C., Zanardi, R., Benedetti, F. |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bipolar Disorder Neuropsychological Tests Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Cognition Internal medicine medicine Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Bipolar disorder Biological Psychiatry Inflammation business.industry Depression Neuropsychology medicine.disease 030227 psychiatry Cognitive functions Psychiatry and Mental health Schizophrenia medicine.symptom Chemokines business Cognition Disorders Mania Neurocognitive 030217 neurology & neurosurgery |
| Zdroj: | Circulating inflammatory markers impact cognitive functions in bipolar depression |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2021.05.071 |
| Popis: | Background Cognitive impairment is a core feature of bipolar disorder, with a prevalence of about 64.4% during episodes and 57.1% in euthymia. Recent evidences suggest that cognitive deficits in BD may follow immune dysfunction and elevated levels of inflammatory cytokines have been reported during periods of depression, mania and euthymia, suggesting the presence of a chronic, low-grade inflammatory state. The aim of the study is to investigate if immune/inflammatory markers and especially chemokines associate to cognitive performances. Methods Seventy-six consecutively admitted inpatients with a depressive episode in course of bipolar disorder performed a neuropsychological evaluation with the Brief Assessment of Cognition in Schizophrenia and plasma blood levels of cytokines, chemokines and growth factors were analyzed with Luminex technology. Results Higher levels of IL-1β, IL-6, CCL2, CCL4, CCL5, CXCL10, and bFGF are associated with the likelihood of having a poor cognitive performance. Limitations Limitation include the lack of a group of healthy controls and the lack of information regarding previous psychopharmacological treatments, alcohol and tobacco use. Conclusions Our results confirm the importance of chemokines in bipolar disorder and suggest that inflammatory markers suggestive of a low-grade inflammatory state could contribute to the neurocognitive deficits observed in depressed patients. |
| Databáze: | OpenAIRE |
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