Immunopathogenesis of ANCA-Associated Vasculitis
| Autor: | Yunryoung Cho, Minha Hwang, Junhye Park, Hyo Jeong Lee, Kang Hyun Kim, Lee Smith, Ji Han Lee, Jae Il Shin, Han Li, Sun Wook Jung, Junseong Park, Hyungjun Kim, Do Young Kim, Andreas Kronbichler, Haejune Sung, Sara Denicolò, Hojune Lee, Geonjae Cho, Dong-Il Kim, Daeun Choi, Philipp Gauckler, Keum Hwa Lee, Dongkyu Lee, Hyung Tae Kim, Jaehyuk Hwang, Ai Koyanagi, Injae Hwang, Sohee Kim, Changjun Lee, Min Je Choi, Louis Jacob, Kalthoum Tizaoui, Donghyun Ahn |
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| Přispěvatelé: | Innsbruck Medical University [Austria] (IMU), Yonsei University, Faculté de médecine - Faculty of Medicine [Sfax, Tunisie] (FMS), Université de Sfax - University of Sfax, University of Florida [Gainesville] (UF), Anglia Ruskin University (ARU), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), ICREA Infection Biology Laboratory (Department of Experimental and Health Sciences), Universitat Pompeu Fabra [Barcelona] (UPF), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Microscopic Polyangiitis Review Churg-Strauss Syndrome urologic and male genital diseases lcsh:Chemistry 0302 clinical medicine Proteinase 3 immune system diseases Eosinophilic skin and connective tissue diseases lcsh:QH301-705.5 Spectroscopy biology treatment ANCA pathogenesis General Medicine Prognosis 3. Good health Computer Science Applications Myeloperoxidase Biomarker (medicine) biomarker Microscopic polyangiitis Granulomatosis with polyangiitis Vasculitis phenotype Myeloblastin Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Serogroup Catalysis Antibodies Antineutrophil Cytoplasmic Inorganic Chemistry 03 medical and health sciences medicine Humans cardiovascular diseases Physical and Theoretical Chemistry Molecular Biology Peroxidase 030203 arthritis & rheumatology business.industry Organic Chemistry Granulomatosis with Polyangiitis medicine.disease respiratory tract diseases 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Immunology biology.protein Personalized medicine business Biomarkers |
| Zdroj: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu International Journal of Molecular Sciences r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.1-27. ⟨10.3390/ijms21197319⟩ International Journal of Molecular Sciences, Vol 21, Iss 7319, p 7319 (2020) |
| ISSN: | 1661-6596 1422-0067 |
| DOI: | 10.3390/ijms21197319⟩ |
| Popis: | International audience; Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small-and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This classification is largely based on clinical presentations and has several limitations. Recent research provided evidence that genetic background, risk of relapse, prognosis, and co-morbidities are more closely related to the ANCA serotype, proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA, compared to the disease phenotypes GPA or MPA. This finding has been extended to the investigation of biomarkers predicting disease activity, which again more closely relate to the ANCA serotype. Discoveries related to the immunopathogenesis translated into clinical practice as targeted therapies are on the rise. This review will summarize the current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers and illustrate how the extending knowledge of the immunopathogenesis will likely translate into development of a personalized medicine approach in the management of ANCA-associated vasculitis. |
| Databáze: | OpenAIRE |
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