Familial longevity is associated with an attenuated thyroidal response to recombinant human thyroid stimulating hormone
| Autor: | Ferdinand Roelfsema, Ana Zutinic, Bart E Ballieux, Gerard J. Blauw, Rudi G. J. Westendorp, Hanno Pijl, Diana van Heemst |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Thyroid Gland/drug effects Thyrotropin/blood endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Thyroid Gland Thyrotropin Biochemistry Thyroxine/blood 0302 clinical medicine Endocrinology Interquartile range Recombinant Proteins/pharmacology Thyroid Clinical Research Article 0303 health sciences responsivity Area under the curve Longevity/genetics Middle Aged Recombinant Proteins medicine.anatomical_structure 030220 oncology & carcinogenesis Triiodothyronine Female AcademicSubjects/MED00250 medicine.medical_specialty endocrine system Triiodothyronine/blood Context (language use) 03 medical and health sciences longevity Internal medicine medicine Humans Adverse effect 030304 developmental biology Aged business.industry Biochemistry (medical) Confidence interval Thyroxine Case-Control Studies Thyroglobulin recombinant human TSH business Hormone |
| Zdroj: | Zutinic, A, Pijl, H, Ballieux, B E, Roelfsema, F, Westendorp, R G J, Blauw, G J & van Heemst, D 2020, ' Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone ', The Journal of clinical endocrinology and metabolism, vol. 105, no. 7, pp. e2572–e2580 . https://doi.org/10.1210/clinem/dgaa195 The Journal of Clinical Endocrinology & Metabolism The Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, 105(7), E2572-E2580. ENDOCRINE SOC |
| DOI: | 10.1210/clinem/dgaa195 |
| Popis: | Context Longevity is associated with higher circulating levels of TSH in the absence of differences in circulating thyroid hormones (TH), as previously observed in F2 members of long-lived families (F2-LLS) and their partners (F2-Con). The mechanism underlying this observed difference remains unknown. Objective We hypothesized that the thyroid gland of members from long-lived families are less responsive to TSH stimulation, thereby requiring higher circulating TSH levels to maintain adequate TH levels. Methods We performed a case-control intervention study with a single intramuscular (gluteal) injection with 0.1 mg recombinant human TSH in a subgroup of 14 F2-LLS and 15 similarly aged F2-Con. They were followed for 4 days. No serious adverse events were reported. For analyses, we compared time trajectories of TSH and TH, and the ratio of TH to TSH using area under the curve (AUC) calculations. Results The AUC free T4/AUC TSH ratio was significantly lower in F2-LLS than in F2-Con (estimated mean [95% confidence interval] 1.6 [1.2-1.9] and 2.2 [1.9-2.6], respectively, P = 0.01). The AUC thyroglobulin/AUC TSH ratio was also lower in F2-LLS than in F2-Con (median [interquartile range] 2.1 [1.4-3.6] and 3.2 [2.7-7.4], respectively, P = 0.04). We observed the same trend with the AUC free T3/AUC TSH ratio, although the difference was not statistically significant (estimated mean [95% confidence interval] 0.6 [0.4-0.7] and 0.7 [0.6-0.8], respectively, P = 0.07). Conclusions The present findings show that members of long-living families have a lower thyroid responsivity to TSH compared with their partners. |
| Databáze: | OpenAIRE |
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