Evaluation of the isoflavones and estrogen effects on the rat adrenal

Autor:	Michele Longoni Calió, Cristiane Paula Teixeira, Adriana Aparecida Ferraz Carbonel, Telma Lisbôa-Nascimento, Darci Souza Marinho, Rodrigo Aquino Castro, Ricardo Simoes, Gui Mi Ko, Clélia Rejane Antônio Bertoncini, M. A. Santos
Rok vydání:	2017
Předmět:	medicine.medical_specialty medicine.drug_class Ovariectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment Caspase 3 Biology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Adrenal Glands medicine Animals Rats Wistar 030219 obstetrics & reproductive medicine Plant Extracts Adrenal gland Uterus Obstetrics and Gynecology Estrogens Hormone replacement therapy (menopause) Isoflavones Rats Oxidative Stress medicine.anatomical_structure chemistry Estrogen 030220 oncology & carcinogenesis Ovariectomized rat Female Phytoestrogens Menopause Oxidative stress
Zdroj:	Gynecological Endocrinology. 33:811-815
ISSN:	1473-0766 0951-3590
Popis:	The aim of this study was to evaluate the morphometry and the gene expression of Ki-67, VEGF and caspase 3 and the stress oxidative in the adrenal gland of ovariectomized rats treated with estrogen or isoflavones. We used 15 Wistar rats ovariectomized treated with isoflavones or estrogen during 30 days. At the end of the treatment, the left adrenal gland was removed for subsequent histological studies and the right was used to evaluate gene expression of angiogenesis (VEGF-A), cell proliferation (Ki-67), apoptose (caspase 3 clivated) and oxidative stress. Treatment with estrogen showed a largest increase in the layers of the adrenal cortex than with isoflavones. These hypertrofic effects agree with higher expression elevation of Ki67 and VEGF, which did not occur with the caspase 3, indicating that isoflavones have great proliferative effect on the adrenal gland. Similar results were also observed on superoxide quantification show that isoflavone has a protective effect against oxidative stress. Our results indicate positively the trophic therapeutic potential of isoflavones has a protective effect and can contribute to the development of effective therapies to decrease the symptoms of menopause.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e5cb98c5c5d1865bc9fd063c27671 https://doi.org/10.1080/09513590.2017.1318371 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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