Isolation and antifungal activity of lignans fromMyristica fragrans against various plant pathogenic fungi
| Autor: | Kyoung Soo Jang, Seung Wan Son, Jun Young Cho, Gyung Ja Choi, Kwang Yun Cho, Jin-Cheol Kim, Nack Do Sung, Sun Og Lee, He Kyoung Lim |
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| Rok vydání: | 2007 |
| Předmět: |
Antifungal Agents
Microbial Sensitivity Tests Colletotrichum coccodes Alternaria alternata Lignans Mass Spectrometry Myristica Myristicaceae chemistry.chemical_compound Botany Magnaporthe grisea Burkholderia glumae Lignan biology Traditional medicine Guaiacol fungi Acidovorax konjaci food and beverages General Medicine Plants biology.organism_classification chemistry Insect Science Seeds Myristica fragrans Agronomy and Crop Science |
| Zdroj: | Pest Management Science. 63:935-940 |
| ISSN: | 1526-4998 1526-498X |
| DOI: | 10.1002/ps.1420 |
| Popis: | BACKGROUND: In a search for plant extracts with potent in vivo antifungal activity against various plant diseases, we found that treatment with a methanol extract of Myristica fragrans Houttyn (nutmeg) seeds reduced the development of various plant diseases. The objectives of the present study were to isolate and determine antifungal substances from My. fragrans and to evaluate their antifungal activities. RESULTS: Three antifungal lignans were isolated from the methanol extract of My. fragrans seeds and identified as erythro-austrobailignan-6 (EA6), meso-dihydroguaiaretic acid (MDA) and nectandrin-B (NB). In vitro antimicrobial activity of the three lignans varied according to compound and target species. Alternaria alternata, Colletotrichum coccodes, C. gloeosporioides, Magnaporthe grisea, Agrobacterium tumefaciens, Acidovorax konjaci and Burkholderia glumae were relatively sensitive to the three lignans. In vivo, all three compounds effectively suppressed the development of rice blast and wheat leaf rust. In addition, EA6 and NB were highly active against the development of barley powdery mildew and tomato late blight, respectively. Both MDA and NB also moderately inhibited the development of rice sheath blight. CONCLUSION: This is the first study to demonstrate the in vitro and in vivo antifungal activities of the three lignans from My. fragrans against plant pathogenic fungi. Copyright © 2007 Society of Chemical Industry |
| Databáze: | OpenAIRE |
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