CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

Autor:	Emma K. Dodds, Jayneeta Gohil, Robert John Ife, Ian Thomson Forbes, Pieter H. E. Groot, Kitty Moores, Theo A. Berkhout, Deirdre M. B. Hickey, David Gwyn Cooper, Martin Stockley, Malcolm L. Meeson
Rok vydání:	2000
Předmět:	Indoles Receptors CCR5 medicine.drug_class Chemokine receptor CCR5 Stereochemistry Receptors CCR2 Clinical Biochemistry Pharmaceutical Science Carboxamide Ligands Biochemistry Chemical synthesis Monocytes chemistry.chemical_compound Structure-Activity Relationship Piperidines Drug Discovery medicine Humans skin and connective tissue diseases Receptor Molecular Biology Chemokine CCL2 biology Molecular Structure Chemistry Drug discovery fungi Organic Chemistry Antagonist Amides body regions Chemotaxis Leukocyte Kinetics biology.protein Molecular Medicine Receptors Chemokine Selectivity Lead compound
Zdroj:	Bioorganicmedicinal chemistry letters. 10(16)
ISSN:	0960-894X
Popis:	A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989de0004444e8338e8626d3a06ea554 https://pubmed.ncbi.nlm.nih.gov/10969972 Zobrazit plný text záznamu Full Text from ScienceDirect