Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice
| Autor: | Sung Keel Kang, Sung Hyun Chung, Sang Gil Lee, Sang Hyun Park |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Cirrhosis medicine.medical_treatment Mice Obese Eleutherococcus Hyperlipidemias Glucosephosphate Dehydrogenase Weight Gain Gene Expression Regulation Enzymologic Mice Liver disease Insulin resistance Weight loss Internal medicine Drug Discovery medicine Animals Insulin Triglycerides Mice Inbred ICR Ethanol biology Plant Extracts Reverse Transcriptase Polymerase Chain Reaction Body Weight Organic Chemistry Fatty liver Glucose Tolerance Test medicine.disease Lipids Fatty Liver Endocrinology Liver Hyperglycemia Solvents biology.protein RNA Molecular Medicine Insulin Resistance Steatosis medicine.symptom Phosphoenolpyruvate Carboxykinase (ATP) Glucose 6-phosphatase |
| Zdroj: | Archives of Pharmacal Research. 29:768-776 |
| ISSN: | 1976-3786 0253-6269 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD) is common in obesity. However, weight reduction alone does not prevent the progression of NAFLD to end-stage disease associated with the development of cirrhosis and liver disease. In a previous experiment, 50% ethanol extract of Acanthopanax senticosus stem bark (ASSB) was found to reduce body weight and insulin resistance in high fat diet-induced hyperglycemic and hyperlipidemic ICR mice. To evaluate the anti-steatosis action of ASSB, insulin-resistant ob/ob mice with fatty livers were treated with ASSB ethanol extract for an 8 week-period. ASSB ethanol extract reversed the hepatomegaly, as evident in reduction of % liver weight/body weight ratio. ASSB ethanol extract also specifically lowered circulating glucose and lipids, and enhanced insulin action in the liver. These changes culminated in inhibition of triglyceride synthesis in non-adipose tissues including liver and skeletal muscle. Gene expression studies confirmed reductions in glucose 6-phosphatase and lipogenic enzymes in the liver. These results demonstrate that ASSB ethanol extract is an effective treatment for insulin resistance and hepatic steatosis in ob/ob mice by decreasing hepatic lipid synthesis. |
| Databáze: | OpenAIRE |
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