Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells

Autor:	C. Lin, Jan Feijen, Martin C. Lok, Zhiyuan Zhong, W.E. Hennink, Holger K. de Wolf, Johannes F.J. Engbersen
Přispěvatelé:	Faculty of Science and Technology, Biomaterials Science and Technology
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Chemistry Pharmaceutical Science Transfection Gene delivery biochemical phenomena metabolism and nutrition medicine.disease Molecular biology In vitro In vivo medicine Side chain Ovarian cancer cells Amine gas treating Ovarian cancer
Zdroj:	ISSUE=10;STARTPAGE=94;ENDPAGE=97;TITLE=10th European Symposium on Controlled Drug Delivery, ESCDD 2008 Journal of controlled release, 132(3), e9-e10. Elsevier
ISSN:	0168-3659
Popis:	Bioreducible poly(amido amine)s (SS-PAAs) with different groups in the side chain were evaluated for gene delivery to ovarian cancer cells, both in vitro and in vivo after intraperitoneal administration in mice bearing an ovarian cancer xenograft. Polyplexes of SS-PAAs with e.g. hydroxybutyl or hydroxypentyl side groups induce much higher transfection in vitro than polyplexes of branched pEI (25 kDa) as a positive control. The in vivo transfection efficiency of polyplexes of SS-PAA with hydroxybutyl side groups is similar to that of linear pEI (22 kDa).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98998ee8d21126bacd0cdab4dd14f882 https://research.utwente.nl/en/publications/bioreducible-polyamido-amines-for-gene-delivery-to-ovarian-cancer-cells(3f51e78a-fc18-4ec5-b44a-3d6014c974b0).html Zobrazit plný text záznamu Full Text from ScienceDirect