Racial Differences in Serum Lipids in HIV+ Women Treated with Protease Inhibitor Regimens
| Autor: | Denise Maceroni, Charles C. J. Carpenter, Melissa DiSpigno, Linda Bausserman, Karen T. Tashima |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty medicine.medical_treatment Human immunodeficiency virus (HIV) Black People Blood lipids Physiology HIV Infections Hyperlipidemias Overweight medicine.disease_cause White People Body Mass Index chemistry.chemical_compound Risk Factors Antiretroviral Therapy Highly Active Internal medicine medicine Humans Insulin Pharmacology (medical) Protease inhibitor (pharmacology) Cholesterol business.industry HIV Protease Inhibitors Middle Aged Anthropometry Lipids Infectious Diseases Endocrinology chemistry Women's Health Female lipids (amino acids peptides and proteins) medicine.symptom business Body mass index |
| Zdroj: | HIV Clinical Trials. 5:399-405 |
| ISSN: | 1945-5771 1528-4336 |
| DOI: | 10.1310/vhba-x9fe-yrqr-yvbk |
| Popis: | To evaluate cardiovascular risk factors in Caucasian and African American HIV+ women undergoing treatment with HAART including a protease inhibitor (PI).Anthropometric measures and fasting blood samples were obtained from 32 Caucasian and 10 African American women. Serum was analyzed for glucose, insulin, and lipid levels.The African American women were significantly older than the Caucasian women. Body mass index (BMI) was higher in the African American women, and 80% of the African American women and 47% of the Caucasian women were overweight. There were no significant differences in fasting insulin, fasting glucose, or HOMA-IR. However, African American women had significantly higher HDL levels, whereas Caucasian women had higher triglycerides and LDL. When age-matched women were compared, total as well as LDL cholesterol was significantly higher in the Caucasian women. The ratio of total cholesterol/HDL cholesterol was 3.4 +/- 1.1 in the African American women and 5.5 +/- 1.6 (p=.021) in the age-matched Caucasian women.The differences in lipid levels in HIV+ African American and Caucasian women were greater than those reported in the literature for normal women. Although the sample size is small, the data suggest that the effect of HIV infection and/or HAART on lipid levels may be different in Caucasian and African American women. Large-scale studies will be necessary to confirm these results and clarify the mechanisms involved. |
| Databáze: | OpenAIRE |
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