Renal impairment in children with cystic fibrosis
| Autor: | Jérôme Harambat, Annick Andrieux, Stéphanie Bui, Albert Iron, Michael Fayon, Fabienne Nacka, Brigitte Llanas |
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| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Adolescent Cystic Fibrosis Renal function urologic and male genital diseases Gastroenterology Cystic fibrosis Liver disease Urolithiasis Antibiotics Internal medicine medicine Odds Ratio Prevalence Albuminuria Humans Hypercalciuria Pediatrics Perinatology and Child Health Longitudinal Studies Renal Insufficiency Nephrotoxicity Child Retrospective Studies Hyperoxaluria business.industry Infant Newborn Infant Odds ratio Kidney disease medicine.disease female genital diseases and pregnancy complications Endocrinology Child Preschool Pediatrics Perinatology and Child Health Microalbuminuria Female France medicine.symptom business Glomerular Filtration Rate |
| Zdroj: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 9(4) |
| ISSN: | 1873-5010 |
| Popis: | Background Due to the improvement in life expectancy in cystic fibrosis (CF), co-morbidities such as renal function impairment may be more frequent. Aim To determine the prevalence of renal disease in children with CF and to identify associated risk factors. Methods A single-center retrospective study analyzing the genetic, clinical and therapeutic characteristics of 112 children. The estimated glomerular filtration rate (GFR), microalbuminuria and lithiasic risk factors were assessed. Results The median calculated GFR (Schwartz) was 123, 161 and 155ml/min/1.73m 2 in children aged 1, 6 and 15years, respectively. The cumulative dose of aminoglycosides was not correlated to GFR. Microalbuminuria was present in 22/38 patients. Hyperoxaluria was observed in 58/83 patients and was associated with a severe genotype, pancreas insufficiency and liver disease. Hypercalciuria, hyperuricuria and hypocitraturia were identified in 16/87, 15/83 and 57/76 patients, respectively. Conclusion Renal impairment in CF has various presentations. There appears to be low levels of renal impairment in children with CF. However, the risk of oxalocalcic urolithiasis is enhanced, and GFR may be underestimated by the Schwartz formula. Further studies using measured GFR techniques are thus warranted. |
| Databáze: | OpenAIRE |
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