Intermediary metabolism of pentachloronitrobenzene in the control and germ-free rat and rat with cannulated bile ducts
| Autor: | Jerome E. Bakke, Gerald L. Larsen, Janice K. Huwe |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Health Toxicology and Mutagenesis Metabolite Administration Oral Urine Toxicology Biochemistry Rats Sprague-Dawley chemistry.chemical_compound Oral administration Toxicokinetics Animals Germ-Free Life Carbon Radioisotopes Mercapturic acid Nitrobenzenes Pharmacology Carbon Isotopes Aniline Compounds Catabolism Pentachloronitrobenzene General Medicine Glutathione Metabolism Fungicides Industrial Rats chemistry Liver Inactivation Metabolic Female Bile Ducts |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 28(10) |
| ISSN: | 0049-8254 |
| Popis: | 1. Nearly 70% of single oral doses of 14C-labelled pentachloronitrobenzene (PCNB) was excreted in bile within 24 h. 2. The characterized biliary metabolites of PCNB were either mercapturic acid pathway metabolites or catabolites thereof (thiols, methylthiols, S-glucuronides). 3. A major biliary metabolite was S-(aminotetrachlorophenyl)glutathione. 4. Conjugation with glutathione with subsequent catabolism to bis-methylthiotetrachlorobenzene was the major pathway in the control rat. 5. Germ-free experiments showed that only nitro- group displacement occurred, and no nitro- group reduction was detected. |
| Databáze: | OpenAIRE |
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