Correlation between high mobility group box-1 protein and chronic hepatitis B infection with severe hepatitis B and acute-on-chronic liver failure: a meta-analysis
| Autor: | Yi-Bing Hu, Rong-Quan Fu, Dan-Ping Hu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Gastroenterology Severity of Illness Index Correlation 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Chronic hepatitis Internal medicine Medicine Humans Acute on chronic liver failure HMGB1 Protein business.industry Acute-On-Chronic Liver Failure General Medicine Knowledge infrastructure Confidence interval Hepatitis a virus Pooled variance 030220 oncology & carcinogenesis Meta-analysis Immunology 030211 gastroenterology & hepatology business |
| Zdroj: | Minerva medica. 108(3) |
| ISSN: | 1827-1669 |
| Popis: | INTRODUCTION The aim of this study was to evaluate the correlation of High-mobility group box 1 (HMGB1) expression in the serum with chronic hepatitis B (CHB) related liver fibrosis, severe hepatitis B and acute-on-chronic liver failure (ACLF). EVIDENCE ACQUISITION We made a literature search in PubMed, Embase, Web of Science, Medline, Google Scholar, China National Knowledge Infrastructure, WanFang with no language restriction. Pooled data were analyzed and mean difference with corresponding 95% confidence intervals were calculated. EVIDENCE SYNTHESIS A total of 16 relevant studies were identified. HMGB1 serum levels were higher in severe hepatitis B or ACLF patients than those in CHB patients. Pooled mean differences of HMGB1 in severe hepatitis B and ACLF patients compared with CHB patients were 4.32 (95% CI: 0.34-8.29, Z=2.13, I2=59%, P=0.03) and 15.96 (95% CI: -0.37-32.28, Z=1.92, P=0.06). Four studies showed there was a different HMGB1 expression in mild, moderate and severe CHB patients (P values were |
| Databáze: | OpenAIRE |
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