Genome-wide association study identifies common variants associated with circulating vitamin E levels
| Autor: | Margaret E. Wright, Peter Kraft, Heather Eliassen, Aditi Hazra, Meredith Yeager, Mark P. Purdue, Stephanie J. Weinstein, Kai Yu, Alison M. Mondul, Kirk Snyder, Hong Zhang, Catherine A. McCarty, Demetrius Albanes, Sara J. Hendrickson, William Wheeler, David J. Hunter, Jacqueline M. Major, Jarmo Virtamo, Stephen J. Chanock, Marilyn C. Cornelis |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_treatment CYP4F2 gamma-Tocopherol Locus (genetics) Genome-wide association study Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide White People Cohort Studies 03 medical and health sciences 0302 clinical medicine Neoplasms Genetics medicine Humans Vitamin E Molecular Biology Genetics (clinical) Aged 030304 developmental biology Genetic association 0303 health sciences Association Studies Articles Genetic Variation General Medicine Middle Aged SCARB1 030220 oncology & carcinogenesis Female Genome-Wide Association Study |
| Zdroj: | Human Molecular Genetics |
| ISSN: | 1460-2083 0964-6906 |
| Popis: | In genome-wide association studies (GWAS) of common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P= 1.7 × 10(-8)) and rs11057830 on 12q24.31 (P= 2.0 × 10(-8)) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P= 2.7 × 10(-10)). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P= 7.8 × 10(-12) (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P= 1.4 × 10(-10) (rs2108622 on 19pter-p13.11 near CYP4F2) and P= 8.2 × 10(-9) (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P1 × 10(-4) identified. |
| Databáze: | OpenAIRE |
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