Lung nodules and IgG4 related disease: a single-center based experience
| Autor: | Tony N. Marion, Yan Xie, Anji Xiong, Yi Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Lung Diseases Male Pulmonary and Respiratory Medicine China medicine.medical_specialty Pleural effusion Lymphadenopathy Bronchi Single Center IgG4 related disease Radiological characteristics parasitic diseases medicine Humans IgG4 related lung disease Lung cancer Glucocorticoids Retrospective Studies lcsh:RC705-779 Lung Clinical characteristics business.industry Mediastinum Retrospective cohort study lcsh:Diseases of the respiratory system Middle Aged respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Lung nodules Female IgG4-related disease Immunoglobulin G4-Related Disease Radiology Differential diagnosis Tomography X-Ray Computed business Immunosuppressive Agents Research Article Calcification |
| Zdroj: | BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-9 (2020) BMC Pulmonary Medicine |
| Popis: | Background This study was undertaken in an attempt to characterize the frequency and clinical features of lung nodules in IgG4 related disease (IgG4-RD) patients as an insight for help with the diagnosis of lung nodules. Methods A retrospective study was carried out in West China Hospital, Sichuan University from January 2012 to December 2018, 89 patients with definite IgG4-RD were enrolled. Results Fifty of 89 patients with definite IgG4-RD had radiologically confirmed lung nodules, 6 of whom were diagnosed with definite IgG4 related lung disease. Lung nodules detected in more than 40 patients were small and solid, always with regular margins. Multiple (41/50) and bilateral (34/50) distributions was also a major characteristic of these lung nodules. Lobulation and speculation were simultaneously detected in 3 patients, including 2 patients combined with pleural indentation. Calcification of nodules was detected in only one patient. Thirty-seven patients also had additional radiological abnormalities of lungs, including ground-glass opacity (21/50), thickening of pleura (9/50), thickening of interlobular septa (4/50), thickening of bronchial wall (3/50), pleural effusion (4/50), mass (3/50), interstitial changes (5/50), and mediastinal or hilar lymphadenopathy (32/50). Most patients (44/50) were treated with glucocorticoids alone or combined with immunosuppressive agents. Sixteen patients received a re-examination by chest computed tomography (CT) scan after treatment, 10 of whom showed a decrease in the size and/or the number of nodules. Conclusions The incidence of lung nodules in IgG4-RD patients can be high. For an IgG4-RD patient with lung nodules, the possibility that the lung nodules related to IgG4-RLD is high. It is hard to differentiate IgG4 related lung nodules from other lung diseases, in particular, lung cancer. Radiological characteristics and positive responses to glucocorticoids and immunosuppressive agents can help with the differential diagnosis. For these patients, regular follow-up is also important. |
| Databáze: | OpenAIRE |
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