24-Hour Serial Spirometric Assessment of Once-Daily Fluticasone Furoate/Umeclidinium/Vilanterol Versus Twice-Daily Budesonide/Formoterol in Patients with COPD: Analysis of the FULFIL Study

Autor: David A. Lipson, Noushin Brealey, Chang-Qing Zhu, Ruby Birk
Rok vydání: 2020
Předmět:
Male
030213 general clinical medicine
Vital capacity
Quinuclidines
Single-inhaler triple therapy
Time Factors
Long-acting β2-agonist
chemistry.chemical_compound
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Inhaled corticosteroid
Forced Expiratory Volume
Pharmacology (medical)
Budesonide
Original Research
COPD
medicine.diagnostic_test
Chronic obstructive pulmonary disease
General Medicine
Middle Aged
Serial FEV1
Fluticasone-Salmeterol Drug Combination
Bronchodilator Agents
030220 oncology & carcinogenesis
Female
Vilanterol
medicine.drug
Spirometry
medicine.medical_specialty
Chlorobenzenes
Fluticasone propionate
03 medical and health sciences
FEV1/FVC ratio
Double-Blind Method
Internal medicine
Administration
Inhalation
medicine
Humans
Benzyl Alcohols
Aged
business.industry
medicine.disease
Lung function
respiratory tract diseases
Androstadienes
Long-acting muscarinic antagonist
chemistry
Budesonide/formoterol
Formoterol
business
Zdroj: Advances in Therapy
ISSN: 1865-8652
Popis: Introduction Few studies have utilized 24-h serial spirometry to compare the effects of inhaled chronic obstructive pulmonary disease (COPD) therapies on lung function. The FULFIL study previously reported significant lung function improvements with once-daily single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus twice-daily single-inhaler budesonide/formoterol (BUD/FOR) in patients with symptomatic COPD at risk of exacerbations. Methods This prespecified analysis evaluated 24-h serial spirometry data from a subgroup of 406 patients in FULFIL. BUD/FOR twice-daily dosing was maintained during 24-h spirometry. A post hoc analysis evaluated serial forced expiratory volume in 1 s (FEV1) at day 1 and week 24 by disease severity at screening (FEV1
Databáze: OpenAIRE
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