Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice
| Autor: | Joseph P. Walton, Elliott J. Brecht, Kathy Barsz, Benjamin Gross |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Inferior colliculus Aging Inhibitory postsynaptic potential Article Vigabatrin 03 medical and health sciences 0302 clinical medicine Mesencephalon medicine Animals Auditory system Hearing Loss Cochlear Nerve gamma-Aminobutyric Acid Neurons General Neuroscience Neural Inhibition Presbycusis Inferior Colliculi Electrophysiology 030104 developmental biology medicine.anatomical_structure Acoustic Stimulation Receptive field 4-Aminobutyrate Transaminase Auditory Perception Mice Inbred CBA Excitatory postsynaptic potential Anticonvulsants Female Neurology (clinical) Geriatrics and Gerontology Tonotopy Psychology Neuroscience 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Neurobiology of Aging. 56:87-99 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.04.003 |
| Popis: | A key feature of age-related hearing loss is a reduction in the expression of inhibitory neurotransmitters in the central auditory system. This loss is partially responsible for changes in central auditory processing, as inhibitory receptive fields play a critical role in shaping neural responses to sound stimuli. Vigabatrin (VGB), an antiepileptic agent that irreversibly inhibits γ-amino butyric acid (GABA) transaminase, leads to increased availability of GABA throughout the brain. This study used multi-channel electrophysiology measurements to assess the excitatory frequency response areas in old CBA mice to which VGB had been administered. We found a significant post-VGB reduction in the proportion of V-type shapes, and an increase in primary-like excitatory frequency response areas. There was also a significant increase in the mean maximum driven spike rates across the tonotopic frequency range of all treated animals, consistent with observations that GABA buildup within the central auditory system increases spike counts of neural receptive fields. This increased spiking is also seen in the rate-level functions and seems to explain the improved low-frequency thresholds. |
| Databáze: | OpenAIRE |
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