Factors associated with bone health status of Malaysian pre-adolescent children in the PREBONE-Kids Study
| Autor: | Wai Yew Yang, Shu Hwa Ong, Karuthan Chinna, Chung Yuan Chang, Kanimolli Arasu, Winnie Siew Swee Chee, Meenal Mavinkurve, Soon Yee Wong, Connie M. Weaver, Megan Hueh Zan Chong, Erwin Jiayuan Khoo |
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| Rok vydání: | 2020 |
| Předmět: |
Peak bone mass
Male medicine.medical_specialty Adolescent Health Status Pre adolescents Bone health Pediatrics Body composition Metabolic equivalent RJ1-570 Absorptiometry Photon Bone Density Tandem Mass Spectrometry Internal medicine medicine Vitamin D and neurology Bone mineral density Humans Vitamin D Child Bone mineral business.industry Calcium prepubertal Malaysia Cross-Sectional Studies Pediatrics Perinatology and Child Health Lean body mass Lumbar spine Female business Chromatography Liquid Research Article |
| Zdroj: | BMC Pediatrics BMC Pediatrics, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2431 |
| Popis: | Background Modifiable lifestyle factors and body composition can affect the attainment of peak bone mass during childhood. This study performed a cross-sectional analysis of the determinants of bone health among pre-adolescent (N = 243) Malaysian children with habitually low calcium intakes and vitamin D status in Kuala Lumpur (PREBONE-Kids Study). Methods Body composition, bone mineral density (BMD), and bone mineral content (BMC) at the lumbar spine (LS) and total body (TB) were assessed using dual-energy X-ray absorptiometry (DXA). Calcium intake was assessed using 1-week diet history, MET (metabolic equivalent of task) score using cPAQ physical activity questionnaire, and serum 25(OH) vitamin D using LC-MS/MS. Results The mean calcium intake was 349 ± 180 mg/day and mean serum 25(OH)D level was 43.9 ± 14.5 nmol/L. In boys, lean mass (LM) was a significant predictor of LSBMC (β = 0.539, p p p p p p p = 0.034) and physical activity measured as MET scores (β = 0.163, p = 0.026) were significant predictors of TBBMD in boys. Among girls, LM was also a significant predictor of LSBMC (β = 0.620, p p p p p = 0.034), TBBMC (β = 0.122, p p = 0.002) in girls. Conclusions LM was the major determinant of BMC and BMD among pre-adolescent Malaysian children alongside other modifiable lifestyle factors such as physical activity and calcium intake. |
| Databáze: | OpenAIRE |
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