Associations of Fatty Liver Disease and Other Factors Affecting Serum SHBG Concentrations: A Population Based Study on 1657 Subjects
| Autor: | M, Flechtner-Mors, A, Schick, S, Oeztuerk, M M, Haenle, M, Wilhelm, W, Koenig, A, Imhof, B O, Boehm, T, Graeter, R A, Mason, W, Kratzer, A S, Akinli, S, Wolff |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Biochemistry Young Adult chemistry.chemical_compound Endocrinology Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine medicine Humans education Aged education.field_of_study Triglyceride biology business.industry Cholesterol Biochemistry (medical) Fatty liver General Medicine Middle Aged medicine.disease Fatty Liver Logistic Models Premenopause chemistry Multivariate Analysis biology.protein Female Metabolic syndrome business Hormone |
| Zdroj: | Hormone and Metabolic Research. 46:287-293 |
| ISSN: | 1439-4286 0018-5043 |
| Popis: | Sex hormone binding globulin (SHBG) is a glycoprotein expressed predominantly in the hepatocytes. It regulates the transport of sex steroid hormones in the blood stream to their target tissues. The expression of the SHBG gene is subject to multifactorial regulation including hormonal, metabolic, and nutritional aspects. Against this background, we investigated the effect of fatty liver and metabolic syndrome, together with other parameters, on serum SHBG concentrations in a population-based cohort in Germany. This cross-sectional study included 870 women and 787 men (average age 42.3±12.8 years), who underwent ultrasound screening for fatty liver in addition to providing a complete medical history and undergoing physical and laboratory examination. Fatty liver was diagnosed on ultrasound criteria in 159 women (18.3%) and 287 men (36.5%). Fatty liver was shown to exert a significant influence on serum SHBG concentrations in men and in premenopausal women. Men with grade 1 fatty liver had a 1.96-fold increased risk (95%-confidence interval=1.28-3.02; p=0.0022) and postmenopausal women with grade 1 fatty liver a 2.4-fold risk (95%-confidence interval=1.11-5.27; p=0.0267) for low SHBG concentrations. Among metabolic parameters, HDL-C represented as affecting factor in men (p=0.0058) and premenopausal women (p=0.0002), while cholesterol only showed an association in premenopausal women (p=0.0439) and triglyceride in postmenopausal women (p=0.0436). No association of concentrations of SHBG and metabolic syndrome was observed. Age, BMI and waist-to-hip ratio also influence the SHBG concentration. Based on these findings, we conclude that fat accumulation in the liver influences SHBG concentrations in men and premenopausal women. |
| Databáze: | OpenAIRE |
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