Expression of cyclin E in dysplasia, carcinoma, and nonmalignant lesions of barrett esophagus

Autor: Nuran Bektas, Wolfram Müller, Hansjörg Heep, Mario Sarbia, Helmut E. Gabbert, Franz Borchard
Rok vydání: 1999
Předmět:
Zdroj: Cancer. 86:2597-2601
ISSN: 1097-0142
0008-543X
DOI: 10.1002/(sici)1097-0142(19991215)86:12<2597::aid-cncr3>3.0.co;2-0
Popis: BACKGROUND Barrett esophagus (BE) is a condition in which the normal squamous epithelium of the esophagus is replaced by metaplastic columnar epithelium. BE is a premalignant lesion because it is the initiating factor in a metaplasia–dysplasia–carcinoma sequence. METHODS Expression of the proliferation-associated molecule cyclin E was immunohistochemically determined in metaplastic specialized epithelium (SE; n = 24), low grade dysplasia (LGD; n = 21), high grade dysplasia (HGD; n = 17), and invasive adenocarcinoma (CA; n = 35) from 36 esophagectomy specimens. In addition, endoscopically obtained samples of SE with minimal inflammatory changes (n = 11) and SE adjacent to erosions or ulcerations were tested for cyclin E expression. RESULTS In the surgical specimens, expression of cyclin E was found in 0 of 24 SE (0%), 2 of 21 LGD (9.5%), 3 of 17 HGD (17.6%), and 5 of 35 CA (14.3%). In the biopsy specimens, expression of cyclin E was found in all samples adjacent to erosions or ulcerations, whereas SE with minimal inflammatory changes was invariably negative for cyclin E. CONCLUSIONS Accumulation of cyclin E can be found by means of immunohistochemistry in premalignant and malignant lesions in BE as well as in regenerative metaplastic epithelium. The determination of cyclin E expression is therefore not useful in the identification of BE patients with an increased risk for the development of carcinoma. Cancer 1999;86:2597–601. © 1999 American Cancer Society.
Databáze: OpenAIRE
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