Cellular Senescence

Autor:	K, Koli, J, Keski-Oja
Rok vydání:	1992
Předmět:	DNA Replication Keratinocytes Cell Death Biochemical Phenomena Antibodies Monoclonal Apoptosis General Medicine Fibroblasts Biochemistry Cell Hypoxia Mice Necrosis Cell Movement Neoplasms Tumor Cells Cultured Animals Humans Cells Cultured Cellular Senescence Skin
Zdroj:	Annals of Medicine. 24:313-318
ISSN:	1365-2060 0785-3890
Popis:	The ageing of cells, cellular senescence, is an event that is encountered in all normal cells. Cells grown in vitro have a limited life span and do not grow well after a certain number of divisions. They cease to divide and eventually die. In accordance with this, the life expectancy of an established cell culture depends on the age of the donor. Cells that have undergone immortalization via a crisis period of transformation by chemicals or viruses, as well as malignant cell lines in general, have an ability to divide indefinitely. A distinct form of cell death, apoptosis or programmed cell death, is encountered in many physiological situations like in keratinocyte differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988324711a20a0b1d31eab7622ab1f5c https://doi.org/10.3109/07853899209147829 Zobrazit plný text záznamu