| Autor: |
Shengyu Cheng, Xianglin Xu, Xinxin Kong, Yudi Jiang, Luxuan Mo, Mingxia Li, Yueying Jin, Yu Han, Xi-Ling Li, Toufeng Jin, Jun Zhe Min |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmaceutical and Biomedical Analysis. 219:114961 |
| ISSN: |
0731-7085 |
| DOI: |
10.1016/j.jpba.2022.114961 |
| Popis: |
Aspirin is a widely used anti-inflammatory drug. It is reported that a relationship may exist between salicylic acid content in plasma and saliva after taking aspirin. This study established a rapid, convenient, and safe method to assess salicylic acid concentration in human saliva. A novel HPLC-ultraviolet detector was used to measure salicylic acid concentrations in human saliva and plasma. A C18 reversed-phase column with an aqueous solution of 0.1% trifluoroacetic acid (TFA)-acetonitrile mobile phase was used, and drug peaks were recorded at 303 nm. Salicylic acid was completely separated in saliva and plasma. Excellent linearity and correlation (r |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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