Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy
| Autor: | Thomas Muehlemann, Martin Biallas, Martin Wolf, Sandra Jasminder Arri, Hans Ulrich Bucher |
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| Přispěvatelé: | University of Zurich, Arri, S J |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Biomedical Engineering 2204 Biomedical Engineering Hemodynamics 610 Medicine & health 3107 Atomic and Molecular Physics and Optics Biomaterials Hemoglobins Cerebral oxygenation Internal medicine medicine Humans Oximetry Cerebral Cortex Analysis of Variance Spectroscopy Near-Infrared business.industry 2502 Biomaterials Near-infrared spectroscopy Significant difference Infant Newborn 2504 Electronic Optical and Magnetic Materials Repeated measures design Reproducibility of Results Oxygenation 10027 Clinic for Neonatology Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Surgery Homogeneous Cardiology Hemoglobinometry Regression Analysis Hemoglobin business Infant Premature |
| Zdroj: | Journal of biomedical optics. 16(4) |
| ISSN: | 1560-2281 |
| Popis: | Background and aim: One source of error with near-infrared spectroscopy (NIRS) is the assumption that the measured tissue is optically homogeneous. This is not always the case. Our aim is to assess the impact of tissue homogeneity (TH) on the precision of NIRS measurements in neonates. Methods: On 36 term and 27 preterm neonates at least five 1-min measurements are performed on each subject using the OxiplexTS. The sensor position is slightly changed before each measurement while assessing TH. The precision for cerebral tissue oxygenation saturation (StO2) and total hemoglobin concentration (tHb) are calculated by repeated measures analysis of variance. Results: The mean StO2 is not significantly different between term and preterm infants. The mean tHb is significantly lower in preterm infants (p < 0.01). With increasing TH, the precision of StO2 increase from 5.6 to 4.6% for preterm and from 11.0 to 2.0% for term infants; the precision of tHb increases from 10.1 to 7.5μM for preterm and from 16.4 to 3.5μM for term infants. The precision for StO2 is higher in term than in preterm infants. The precision for tHb shows no significant difference between the two groups. Conclusions: The precision of NIRS measurements correlates with tissue homogeneity. |
| Databáze: | OpenAIRE |
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