Symptomatic features and prognosis of 932 hospitalized patients with coronavirus disease 2019 in Wuhan
| Autor: | Ji Zhong Yin, Yu Shi Hao, Ping Fang Hu, Chen Wang, Ya Long Liu, Chuan Yin, Qiong Wang, Zheng Qing Zhao, Wei Chen, Yu Sheng Wang, Jian Wang, Bei Fang Ning, Liang Liang Sun, Cheng Chen, Wei Fen Xie, Hai Huang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Nausea Anorexia Severity of Illness Index SARS‐CoV‐2 03 medical and health sciences symptomatic feature 0302 clinical medicine COVID‐19 Internal medicine medicine Humans Aged Retrospective Studies Aged 80 and over SARS-CoV-2 business.industry Incidence (epidemiology) Gastroenterology COVID-19 Retrospective cohort study Original Articles Odds ratio Middle Aged Prognosis Confidence interval Dysgeusia Hospitalization 030220 oncology & carcinogenesis Vomiting Female Original Article 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Journal of Digestive Diseases |
| ISSN: | 1751-2980 1751-2972 |
| DOI: | 10.1111/1751-2980.12983 |
| Popis: | Objective To discern the symptomatic features of coronavirus disease 2019 (COVID‐19) and to evaluate the severity and prognosis of the disease. Methods In this retrospective cohort study, 932 hospitalized patients with COVID‐19 in Wuhan were enrolled, including 52 severe and 880 non‐severe cases. All patients were followed up for 3 months after discharge. The symptomatic features and follow‐up data of the patients in both groups were analyzed and compared. Results Of the 932 patients, fever (60.0%), cough (50.8%) and fatigue (36.4%) were the most common symptoms. In total, 32.7% of the severe cases presented with gastrointestinal symptoms at disease onset, including anorexia, nausea, vomiting or diarrhea, which was significantly higher than that of the non‐severe group (P = 0.0015). The incidence of olfactory disturbance and dysgeusia was only 3.1% and 6.2%, respectively. After adjusting for age and sex, multivariate regression analysis showed that fever lasting for over 5 days (odds ratio [OR] 1.90, 95% confidence interval [CI] 1.00‐3.62, P = 0.0498), anorexia at onset (OR 2.61, 95% CI 1.26‐5.40, P = 0.0096), and modified Medical Research Council level above grade 2 when dyspnea occurred (OR 14.19, 95% CI 7.01‐28.71, P Clinical courses of major symptoms and duration of viral shedding from illness onset in patients hospitalized with coronavirus disease 2019. |
| Databáze: | OpenAIRE |
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