Distinct Innate Immune Gene Expression Profiles in Non-Melanoma Skin Cancer of Immunocompetent and Immunosuppressed Patients

Autor: Tissa Hata, Monika Gerber, Shang Brian Jiang, Julie Akiko Gladsjo, Richard L. Gallo, Beda Muehleisen
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Skin Neoplasms
TRAF1
lcsh:Medicine
0302 clinical medicine
lcsh:Science
Immune Response
Melanoma
0303 health sciences
Multidisciplinary
integumentary system
Toll-Like Receptors
Cell Differentiation
Innate Immunity
3. Good health
Gene Expression Regulation
Neoplastic
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Medicine
Cytokines
Tumor necrosis factor alpha
Female
Immunocompetence
Research Article
Signal Transduction
Immunology
Malignant Skin Neoplasms
Dermatology
Biology
Immunomodulation
03 medical and health sciences
Immunocompromised Host
Immune system
medicine
Humans
Basal cell carcinoma
RNA
Messenger
neoplasms
030304 developmental biology
Aged
Innate immune system
Gene Expression Profiling
lcsh:R
Immunity
Immunoregulation
Organ Transplantation
medicine.disease
Immunity
Innate
stomatognathic diseases
Carcinoma
Basal Cell
Immune System
lcsh:Q
Skin cancer
Epidermis
Antimicrobial Cationic Peptides
Genes
Neoplasm
Zdroj: PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40754 (2012)
ISSN: 1932-6203
Popis: Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are the most frequent skin cancers in humans. An intact immune system is critical for protection against SCC since organ transplant recipients (OTR) have a 60- to 100-fold higher risk for developing these tumors. The role of the innate immune system in tumor immunosurveillance is unclear. Our aim was to determine the expression of selected innate immune genes in BCC and SCC arising in immunocompetent and OTR patients. Lesional and peri-lesional skin from 28 SCC and 19 BCC were evaluated for mRNA expression of toll-like receptors (TLR) 1–9, downstream TLR signaling molecules, and antimicrobial peptides. 11 SCC occurring in OTR patients were included in the analysis. We found that SCC but not BCC showed significantly elevated expression of TLRs 1–3, 5–8, TRIF and TRAF1. TNF was increased in SCC compared to normal skin. BCC showed increased IFNγ. hBD1, hBD2 and psoriasin mRNA and protein expression were significantly higher in SCC than in normal skin and higher than in BCC. SCC from OTR showed only an increase in hBD2 but no increase in hBD1 or psoriasin. We conclude that innate immune gene expression in SCC is distinct from normal skin and BCC. BCC shows lesser induction of innate immune genes. SCC from OTR patients have depressed expression of hBD1 and psoriasin compared to SCC from immunocompetent patients.
Databáze: OpenAIRE
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