Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents

Autor:	Kwang-Seop Song, Suk Ho Lee, Hyun-Ju Park, Jeongmin Kim, Jong Yup Kim, Seung-Hwan Cho, Misuk Kang, Jinhwa Lee, Jun Sung Lee
Rok vydání:	2011
Předmět:	Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Thiophenes Ring (chemistry) Biochemistry Thiophene derivatives In vitro Structure-Activity Relationship chemistry.chemical_compound Glucosides Sodium-Glucose Transporter 2 chemistry Glucoside Drug Discovery Thiophene Hypoglycemic Agents Molecular Medicine Structure–activity relationship Benzhydryl Compounds Sodium-Glucose Transporter 2 Inhibitors Molecular Biology Antidiabetic agents
Zdroj:	Bioorganic & Medicinal Chemistry. 19:5813-5832
ISSN:	0968-0896
Popis:	Novel thiophene C-aryl glucoside SGLT2 inhibitors were designed and synthesized. Two different types of thiophene derivatives were readily prepared. Among the compounds tested, ethylphenyl at the distal ring 71p showed the best in vitro inhibitory activity in this series to date (IC(50)=4.47 nM) against SGLT2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987f606e2db287339e5138d7b89429d3 https://doi.org/10.1016/j.bmc.2011.08.014 Zobrazit plný text záznamu Full Text from ScienceDirect