Use of Tetravalent Galabiose for Inhibition of Streptococcus Suis Serotype 2 Infection in a Mouse Model
| Autor: | Sauli Haataja, Hanne Møller Mortensen, Hans Christian Slotved, Roland J. Pieters, John A. F. Joosten, Karen A. Krogfelt, Hilbert M. Branderhorst, Lene Arler, Jukka Finne |
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| Přispěvatelé: | Biosciences, Glycoscience Group |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Serotype
experimental infections potency Streptococcus suis efficacy Antibiotics chemotherapy antibiotics Pathogen lcsh:QH301-705.5 1183 Plant biology microbiology virology 0303 health sciences bacterial diseases Streptococcus suis serotype 2 Zoonotic Infection adhesion inhibition bactericidal properties meningitis adhesions tetravalent galabiose bacterium zoonotic infections drug therapy 3. Good health arthritis penicillins General Agricultural and Biological Sciences hogs medicine.drug septicaemia medicine.drug_class mouse model education Biology General Biochemistry Genetics and Molecular Biology Article Microbiology 03 medical and health sciences In vivo medicine antibacterial properties peritonitis 030304 developmental biology disease models blood poisoning General Immunology and Microbiology 030306 microbiology septicemia swine biology.organism_classification Virology zoonoses Penicillin serotypes bacterial infections lcsh:Biology (General) 1182 Biochemistry cell and molecular biology bacterioses |
| Zdroj: | Biology, Vol 2, Iss 2, Pp 702-718 (2013) Biology Volume 2 Issue 2 Pages 702-718 |
| ISSN: | 2079-7737 |
| Popis: | Streptococcus suis is an important swine pathogen associated with a variety of infections such as meningitis, arthritis and septicemia. The bacterium is zoonotic and has been found to cause meningitis especially in humans occupationally exposed to infected pigs. Since adhesion is a prerequisite for colonization and subsequent infection, anti-adhesion treatment seems a natural alternative to traditional treatment with antibiotics. In order to optimize the inhibitory potency a multivalency approach was taken in the inhibitor design. A synthetic tetravalent galabiose compound was chosen which had previously shown promising anti-adhesion effects with S. suis in vitro. The aim of this study was to evaluate the in vivo effects of the compound using an infection peritonitis mouse model. As such S. suis serotype 2 infection and treatment were tested in vivo and the effects were compared to the effect of treatment with penicillin. |
| Databáze: | OpenAIRE |
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