Meiotic sex in Chagas disease parasite Trypanosoma cruzi
| Autor: | Philipp Schwabl, Frederik Van den Broeck, Jalil Maiguashca-Sánchez, Mario J. Grijalva, Björn Andersson, Martin S. Llewellyn, Hideo Imamura, Jaime A. Costales, Michael A. Miles |
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| Přispěvatelé: | Clinical sciences, Medical Genetics, Faculty of Sciences and Bioengineering Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Population genetics DIVERSITY RECOMBINATION General Physics and Astronomy 02 engineering and technology Genome Chiroptera lcsh:Science Recombination Genetic education.field_of_study Multidisciplinary Transmission (medicine) Reproduction GENETIC EXCHANGE 021001 nanoscience & nanotechnology 3. Good health Multidisciplinary Sciences GENOME Meiosis Science & Technology - Other Topics Ecuador Triatominae 0210 nano-technology Chagas disease CLONALITY BRUCEI-BRUCEI TRANSMISSION Trypanosoma cruzi Science Population Virulence Rodentia LEISHMANIA-INFANTUM Biology Article Evolutionary genetics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Genetic variation parasitic diseases medicine Animals Chagas Disease education Ecological epidemiology Science & Technology Host (biology) Parasite genomics Genetic Variation Sequence Analysis DNA General Chemistry medicine.disease biology.organism_classification EVOLUTION Genetics Population 030104 developmental biology Evolutionary biology lcsh:Q Genome Protozoan GENERATION |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Genetic exchange enables parasites to rapidly transform disease phenotypes and exploit new host populations. Trypanosoma cruzi, the parasitic agent of Chagas disease and a public health concern throughout Latin America, has for decades been presumed to exchange genetic material rarely and without classic meiotic sex. We present compelling evidence from 45 genomes sequenced from southern Ecuador that T. cruzi in fact maintains truly sexual, panmictic groups that can occur alongside others that remain highly clonal after past hybridization events. These groups with divergent reproductive strategies appear genetically isolated despite possible co-occurrence in vectors and hosts. We propose biological explanations for the fine-scale disconnectivity we observe and discuss the epidemiological consequences of flexible reproductive modes. Our study reinvigorates the hunt for the site of genetic exchange in the T. cruzi life cycle, provides tools to define the genetic determinants of parasite virulence, and reforms longstanding theory on clonality in trypanosomatid parasites. Here, Llewellyn and colleagues present evidence of meiotic sex in Trypanosoma cruzi, the causative agent of Chagas disease. These findings have implications for the epidemiology of the disease in endemic regions and challenge existing ideas that the parasites are strictly clonal. |
| Databáze: | OpenAIRE |
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