A role for human skin-resident T cells in wound healing
| Autor: | Kristen R. Taylor, Ross Rudolph, Mayer Tenenhaus, Dhaval Bhavsar, Julie M. Jameson, Lionel Breton, Antoine Toulon, Caroline Lanigan, Wendy L. Havran |
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| Rok vydání: | 2009 |
| Předmět: |
Chronic wound
Male Pathology medicine.medical_specialty medicine.medical_treatment T-Lymphocytes Immunology Foreskin Human skin Biology Organ culture Lymphocyte Activation 03 medical and health sciences 0302 clinical medicine Organ Culture Techniques Skin Physiological Phenomena medicine Immunology and Allergy Humans Insulin-Like Growth Factor I Tissue homeostasis 030304 developmental biology Skin Skin repair 0303 health sciences Wound Healing Epidermis (botany) integumentary system Growth factor Brief Definitive Report Flow Cytometry Cell biology Chronic Disease medicine.symptom Epidermis Wound healing 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 |
| Popis: | Epidermal T cells have been shown to play unique roles in tissue homeostasis and repair in mice through local secretion of distinct growth factors in the skin. Human epidermis contains both alphabeta(+) and gammadelta(+) T cells whose functional capabilities are not understood. We demonstrate that human epidermal T cells are able to produce insulin-like growth factor 1 (IGF-1) upon activation and promote wound healing in a skin organ culture model. Moreover, an analysis of the functional capabilities of T cells isolated from acute versus chronic wounds revealed a striking difference. Both alphabeta(+) and Vdelta1(+) T cells isolated from acute wounds actively produced IGF-1, demonstrating that they are activated during tissue damage to participate in wound repair. In contrast, IGF-1 production could not be detected in T cells isolated from chronic wounds. In fact, skin T cells isolated from chronic wounds were refractory to further stimulation, suggesting an unresponsive state. Collectively, these results define a novel role for human epidermis-resident T cells in wound healing and provide new insight into our understanding of chronic wound persistence. |
| Databáze: | OpenAIRE |
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