Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies

Autor: Thomas Häder, Kurt Schönfeld, Christoph Uherek, Chantal Zuber, Jan Pinkas, Katrin Bernöster
Jazyk: angličtina
Předmět:
0301 basic medicine
medicine.medical_specialty
Indatuximab ravtansine
Cancer Research
Immunoconjugates
Drug Evaluation
Preclinical
Pharmacology
lcsh:RC254-282
Dexamethasone
03 medical and health sciences
Mice
0302 clinical medicine
In vivo
Multiple myeloma
Internal medicine
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
medicine
Animals
Humans
Maytansine
Drug combination
Lenalidomide
Letter to the Editor
Molecular Biology
Tumour regression
Hematology
business.industry
lcsh:RC633-647.5
Antibodies
Monoclonal
lcsh:Diseases of the blood and blood-forming organs
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Thalidomide
030104 developmental biology
Oncology
Cell culture
030220 oncology & carcinogenesis
Monoclonal
Pre-clinical
Cancer research
Syndecan-1
business
medicine.drug
Zdroj: Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-4 (2017)
ISSN: 1756-8722
DOI: 10.1186/s13045-016-0380-0
Popis: Indatuximab ravtansine is a monoclonal antibody-linked cytotoxic agent that specifically targets CD138-expressing cells. Monotherapy has been shown to significantly inhibit multiple myeloma tumour growth in vivo and improve host survival. Here, we show that in most cell lines tested, indatuximab ravtansine acts additively or even synergistically with clinically approved therapies for treatment of multiple myeloma. In addition, in vivo mouse xenograft models confirmed the activity of indatuximab ravtansine in combination with lenalidamide and lenalidomide/dexamethasone. Indatuximab ravtansine may therefore be a suitable combination partner for multiple myeloma, and a clinical study is ongoing. Electronic supplementary material The online version of this article (doi:10.1186/s13045-016-0380-0) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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