A Parametric Computational Model of the Action Potential of Pacemaker Cells
| Autor: | Sidharta Andalam, Mark L. Trew, Partha S. Roop, Avinash Malik, Nitish Patel, Weiwei Ai, Nathan Allen, Eugene Yip |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Computer science
Sinoatrial node 0206 medical engineering Models Cardiovascular Biomedical Engineering Action Potentials 02 engineering and technology 030204 cardiovascular system & hematology 020601 biomedical engineering Atrioventricular node 03 medical and health sciences Nonlinear system Pacemaker action potential Electrophysiology 0302 clinical medicine medicine.anatomical_structure Heart Conduction System Control theory medicine Humans Action potential duration Pacemaker cell Hybrid automaton Parametric statistics |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 65:123-130 |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2017.2695537 |
| Popis: | Objective: A flexible, efficient, and verifiable pacemaker cell model is essential to the design of real-time virtual hearts that can be used for closed-loop validation of cardiac devices. A new parametric model of pacemaker action potential is developed to address this need. Methods: The action potential phases are modeled using hybrid automaton with one piecewise-linear continuous variable. The model can capture rate-dependent dynamics, such as action potential duration restitution, conduction velocity restitution, and overdrive suppression by incorporating nonlinear update functions. Simulated dynamics of the model compared well with previous models and clinical data. Conclusion: The results show that the parametric model can reproduce the electrophysiological dynamics of a variety of pacemaker cells, such as sinoatrial node, atrioventricular node, and the His-Purkinje system, under varying cardiac conditions. Significance: This is an important contribution toward closed-loop validation of cardiac devices using real-time heart models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|