COVID-19 in Adults With Congenital Heart Disease
| Autor: | Jamil Aboulhosn, Francisco J. Ruperti-Repilado, Ian Lindsay, Anitha S. John, Heather L. Bartlett, Harsimran Singh, Stacy D. Fisher, Timothy B. Cotts, Elizabeth Yeung, Matthew R. Carazo, Laith Alshawabkeh, Kristi Ryan, Jong M. Ko, David Gregg, Arsha Karbassi, Jennifer R. Maldonado, Lauren Andrade, Ari Cedars, Prashob Porayette, Shailendra Upadhyay, Payam Dehghani, John J. Araujo, Fred H. Rodriguez, Francisca Arancibia Galilea, Jonathan W. Cramer, Adrienne H. Kovacs, Marlon Rosenbaum, Benjamin P. Frischhertz, Eric V. Krieger, Sébastien Hascoët, Scott Cohen, Dan G. Halpern, George Giannakoulas, Hassan Almeneisi, Jeremy Nicolarsen, Christopher R. Broda, Craig S. Broberg, Arvind K. Hoskoppal, Daniel Tobler, Jasmine Grewal, Poyee P. Tung, Carla P. Rodriguez-Monserrate, Anisa Chaudhry, George K. Lui, Flavia Fusco, Khalid Al Najashi, Jodi L. Feinberg, Scott E. Klewer, Soraya Sadeghi, Berto J. Bouma, Markus Schwerzmann, Berardo Sarubbi, Judith Bouchardy, Amiram Nir, Paolo Ferrero, Matthias Greutmann, Salwa M. Gendi, Benjamin Hendrickson, Efren Martinez-Quintana, Matthew J. Lewis, Georges Ephrem, Stephen Cook, Rose O. Tompkins, Magalie Ladouceur, Alexandra Frogoudaki, Fernando Baraona, Pablo Meras, Shabnam Mohammadzadeh, Rocio Garcia-Orta |
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| Přispěvatelé: | Cardiology, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics Heart disease coronavirus Comorbidity 030204 cardiovascular system & hematology Global Health law.invention 0302 clinical medicine PCR polymerase chain reaction COVID-19 Testing law Risk Factors 030212 general & internal medicine 610 Medicine & health Original Investigation education.field_of_study COVID-19 coronavirus disease-2019 eGFR estimated glomerular filtration rate Intensive care unit ICU intensive care unit Hospitalization Causality Cohort Female PAH pulmonary arterial hypertension Symptom Assessment Cardiology and Cardiovascular Medicine hospitalization Adult Heart Defects Congenital medicine.medical_specialty Hypertension Pulmonary Population Article 03 medical and health sciences Diabetes mellitus medicine adult congenital heart disease Humans Cardiac Surgical Procedures Mortality education Cyanosis business.industry SARS-CoV-2 Patient Acuity COVID-19 medicine.disease Pulmonary hypertension CI confidence interval OR odds ratio CHD congenital heart disease Heart failure business |
| Zdroj: | J Am Coll Cardiol Journal of the American College of Cardiology, 77(13), 1644-1655. Elsevier USA Journal of the American College of Cardiology |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2021.02.023 |
| Popis: | Background Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. Objectives This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. Methods Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. Results From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 ± 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. Conclusions COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. Central Illustration |
| Databáze: | OpenAIRE |
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