Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses
| Autor: | Ming-Hsiang Hong, Fu-Tong Liu, I-Chun Weng, Fang-Yen Li, Wei-Han Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Glycan Glycans animal structures Galectins Endocrinology Diabetes and Metabolism Clinical Biochemistry Carbohydrates Cellular homeostasis lcsh:Medicine Review Biology 03 medical and health sciences 0302 clinical medicine Polysaccharides Organelle Sense (molecular biology) otorhinolaryngologic diseases Autophagy Animals Humans Pharmacology (medical) Molecular Biology Galectin Biochemistry (medical) lcsh:R Cell Biology General Medicine Cell biology stomatognathic diseases 030104 developmental biology Endocytic vesicle biology.protein Carbohydrate Metabolism Infection 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-9 (2021) Journal of Biomedical Science |
| ISSN: | 1423-0127 |
| Popis: | Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins. |
| Databáze: | OpenAIRE |
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