Lack of efficacy of propofol in the treatment of early postoperative nausea and vomiting
| Autor: | E. Della-Marta, J. L. Plummer, Harry Owen, I. Harper, Anthony H. Ilsley |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Nausea Sedation Critical Care and Intensive Care Medicine Placebo 03 medical and health sciences 0302 clinical medicine Gynecologic Surgical Procedures medicine Antiemetic Humans Single-Blind Method 030212 general & internal medicine Propofol business.industry 030208 emergency & critical care medicine Middle Aged Surgery Anesthesiology and Pain Medicine Treatment Outcome Anesthesia Injections Intravenous Postoperative Nausea and Vomiting Vomiting Antiemetics Female Laparoscopy medicine.symptom business Droperidol Postoperative nausea and vomiting medicine.drug |
| Zdroj: | Anaesthesia and intensive care. 26(4) |
| ISSN: | 0310-057X |
| Popis: | The anti-nauseant efficacy of low-dose propofol was investigated in a blinded, randomized trial. Patients who complained of nausea and/or vomiting following laparoscopic gynaecological surgery and who requested antiemetic were randomly assigned to receive placebo, propofol 3 mg, propofol 9 mg or propofol 27 mg by intravenous injection. Nausea, vomiting and sedation were recorded by a blinded observer for 90 minutes following administration of the test drug, prior to discharge, and 24 hours following surgery. Rescue antiemetic (droperidol 1.0 mg IV) was available from 10 minutes after administration of test drug. Propofol failed to reduce nausea scores and did not reduce the incidence of vomiting. Numbers of patients receiving rescue antiemetic were similar in the four treatment groups. In the first 10 minutes following test drug administration, sedation scores were increased by propofol in a dose-related manner. We conclude that, in the dose range studied, propofol is ineffective for the treatment of nausea and vomiting occurring soon after laparoscopic gynaecological surgery. |
| Databáze: | OpenAIRE |
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