Lipasin/Betatrophin Is Differentially Expressed in Liver and White Adipose Tissue Without Association With Insulin Resistance in Wistar and Goto-Kakizaki Rats
| Autor: | David Habart, Tomas Olejar, Frantisek Saudek, A. Lodererova, Zuzana Papackova, Zuzana Berková, Monika Cahova, Marie Heczkova, Helena Daňková |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Betatrophin Adipose Tissue White Peptide Hormones Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes White adipose tissue Goto kakizaki 03 medical and health sciences 0302 clinical medicine Insulin resistance Species Specificity Angiopoietin-Like Protein 8 Internal medicine medicine Animals Rats Wistar business.industry Insulin sensitivity General Medicine medicine.disease Rats Angiopoietin-like Proteins 030104 developmental biology Endocrinology Gene Expression Regulation Liver Organ Specificity Insulin Resistance Lipokine business |
| Zdroj: | Europe PubMed Central Scopus-Elsevier ResearcherID |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.933339 |
| Popis: | Lipasin is a recently identified lipokine expressed predominantly in liver and in adipose tissue. It was linked to insulin resistance in mice and to type 1 and type 2 diabetes (T1D, T2D) in humans. No metabolic studies concerning lipasin were performed yet in rats. Therefore, we used rat model of T2D and insulin resistance, Goto-Kakizaki (GK) rats, to determine changes of lipasin expression in liver and in white adipose tissue (WAT) over 52 weeks in the relation to glucose tolerance, peripheral tissue insulin sensitivity and adiposity. GK rats were grossly glucose intolerant since the age of 6 weeks and developed peripheral insulin resistance at the age of 20 weeks. Expression of lipasin in the liver did not differ between GK and Wistar rats, declining with age, and it was not related to hepatic triacylglycerol content. In WAT, the lipasin expression was significantly higher in Wistar rats where it correlated positively with adiposity. No such correlation was found in GK rats. In conclusion, lipasin expression was associated neither with a mild age-related insulin resistance (Wistar), nor with severe genetically-based insulin resistance (GK). |
| Databáze: | OpenAIRE |
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