Prognosis in primary effusion lymphoma is associated with the number of body cavities involved

Autor:	Jorge J. Castillo, Majid Lahijani, Helen Shum, James N. Butera, Eric S. Winer
Rok vydání:	2012
Předmět:	Adult Male Cancer Research medicine.medical_specialty Pathology CD30 Ki-1 Antigen Kaplan-Meier Estimate Gastroenterology Sex Factors immune system diseases hemic and lymphatic diseases Internal medicine Lymphoma Primary Effusion medicine Humans In patient Body cavity Peritoneal Cavity Aged CD20 Aged 80 and over Pleural Cavity biology business.industry virus diseases Hematology Middle Aged medicine.disease Antigens CD20 Prognosis Lymphoma Pleural Effusion Malignant Review Literature as Topic medicine.anatomical_structure Oncology Effusion Herpesvirus 8 Human Host-Pathogen Interactions biology.protein Female Primary effusion lymphoma business Pericardium Male predominance
Zdroj:	Leukemialymphoma. 53(12)
ISSN:	1029-2403
Popis:	Primary effusion lymphoma (PEL) is a rare lymphoma associated with Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), and characterized by a malignant body cavity effusion without solid organ or nodal involvement. Prognostic factors in patients with PEL have not been systematically studied. We conducted a literature search for patients with HHV8-positive PEL to identify potential prognostic factors for survival. Our search identified 147 patients, among which 104 patients were HHV8-positive. The median overall survival was 9 months. The median age was 57 years with a male predominance (6:1). Pathologically, 33% of the patients expressed CD20 and 69% expressed CD30. Patients with PEL with1 body cavity involved had a median overall survival (OS) of 4 months compared with 18 months in patients with only one cavity involved (p = 0.003). Additionally, in patients with one involved body cavity, pericardial involvement was associated with a longer median OS than pleural followed by peritoneal involvement (40, 27 and 5 months, respectively; p = 0.04). In conclusion, our study suggests that the number and location of body cavities involved are prognostic in patients with PEL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9874b109e3d1b4dd74269c467acc27d2 https://pubmed.ncbi.nlm.nih.gov/22591071 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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