Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons
| Autor: | Kevin T. Beier, Franz Weber, Yang Dan, Mike Bikov, Mohammad Saffari Doost, Johnny Phong Hoang Do, Shinjae Chung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
General Physics and Astronomy Polysomnography Mice 0302 clinical medicine Pons Neural Pathways Periaqueductal Gray GABAergic Neurons lcsh:Science skin and connective tissue diseases Multidisciplinary medicine.diagnostic_test Chemistry musculoskeletal neural and ocular physiology Brain Ultradian Rhythm Electroencephalography Sleep in non-human animals Mental Health Neurological GABAergic Sleep onset Sleep Research psychological phenomena and processes Science Sleep REM Periaqueductal gray Non-rapid eye movement sleep General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences MD Multidisciplinary mental disorders medicine Animals Ultradian rhythm Electromyography Neurosciences General Chemistry 030104 developmental biology REM lcsh:Q Calcium sense organs Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018) Nature communications, vol 9, iss 1 Nature Communications Weber, F; Hoang Do, JP; Chung, S; Beier, KT; Bikov, M; Saffari Doost, M; et al.(2018). Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons. Nature Communications, 9(1), 354. doi: 10.1038/s41467-017-02765-w. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/6w5694hh |
| ISSN: | 2041-1723 |
| Popis: | Mammalian sleep consists of distinct rapid eye movement (REM) and non-REM (NREM) states. The midbrain region ventrolateral periaqueductal gray (vlPAG) is known to be important for gating REM sleep, but the underlying neuronal mechanism is not well understood. Here, we show that activating vlPAG GABAergic neurons in mice suppresses the initiation and maintenance of REM sleep while consolidating NREM sleep, partly through their projection to the dorsolateral pons. Cell-type-specific recording and calcium imaging reveal that most vlPAG GABAergic neurons are strongly suppressed at REM sleep onset and activated at its termination. In addition to the rapid changes at brain state transitions, their activity decreases gradually between REM sleep and is reset by each REM episode in a duration-dependent manner, mirroring the accumulation and dissipation of REM sleep pressure. Thus, vlPAG GABAergic neurons powerfully gate REM sleep, and their firing rate modulation may contribute to the ultradian rhythm of REM/NREM alternation. The vlPAG in the midbrain is known to suppress REM sleep, but the precise neural correlates are not known. Here, the authors record the activity of vlPAG GABAergic neurons during the sleep–wake cycle and report fast changes at REM sleep transitions and slower changes that correlate with REM sleep pressure. |
| Databáze: | OpenAIRE |
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