Recent Updates in Melanocyte Function: The Use of Promising Bioactive Compounds for the Treatment of Hypopigmentary Disorders
| Autor: | Kamal Uddin Zaidi, Ayesha S. Ali, Sharique A. Ali, Ishrat Naaz |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tyrosinase Biology Melanocyte Skin Diseases Melanin Structure-Activity Relationship 03 medical and health sciences Melanin synthesis Drug Discovery medicine Animals Humans Hypopigmentation Melanins Pharmacology Dose-Response Relationship Drug Molecular Structure integumentary system General Medicine Dermatology Abnormal skin pigmentation 030104 developmental biology medicine.anatomical_structure Melanocytes medicine.symptom Melanin pigment Neuroscience Function (biology) |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 17:785-798 |
| ISSN: | 1389-5575 |
| Popis: | Background: Skin pigmentation is a broadly appearing phenomenon in nature which plays an important task of determining the appearance and biology of all vertebrates including human beings. Skin color is a crucial attribute, determined by the synthesis of melanin pigment within melanocytes by the process of melanogenesis and is regulated by many extrinsic as well as intrinsic factors. Tyrosinase catalyzes the key step of melanogenesis, dysfunction of tyrosinase leads to reduce melanin production which results in severe clinical and aesthetical problems of hypopigmentation. Therefore, the regulation of melanin production is an important strategy in the treatment of abnormal skin pigmentation for cosmetic and medicinal purpose. Method: The present review covers the various aspects of mammalian melanocyte biology which will help in the identification of key regulators of melanogenesis from pharmaceutical and pharmacological point of view. Further sections of the review focus on the dysfunctions of melanogenic pathways, which result in severe clinical and aesthetical problems of hypopigmentation. Conclusion: We have also attempted to highlight the ability of available scientifically validated plant extracts to naturally enhance melanin synthesis in order to cure hypopigmentation. |
| Databáze: | OpenAIRE |
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