Glutamate-sensitive imaging and evaluation of cognitive impairment in multiple sclerosis
| Autor: | Lydia J McKeithan, Bennett A. Landman, Bailey Lyttle, Adrienne N. Dula, Francesca Bagnato, Kristin P. O’Grady, Bailey A. Box, Siddharama Pawate, Paul A. Newhouse, Lindsey M. Thompson, Seth A. Smith, Benjamin N. Conrad |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Multiple Sclerosis Glutamic Acid Dysfunctional family Article 03 medical and health sciences 0302 clinical medicine medicine Humans Cognitive Dysfunction 030212 general & internal medicine Gray Matter Cognitive impairment Prefrontal cortex Cerebral Cortex medicine.diagnostic_test business.industry Multiple sclerosis Glutamate receptor Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging White Matter Neurology Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Mult Scler |
| ISSN: | 1477-0970 |
| Popis: | Background: Cognitive impairment (CI) profoundly impacts quality of life for patients with multiple sclerosis (MS). Dysfunctional regulation of glutamate in gray matter (GM) has been implicated in the pathogenesis of MS by post-mortem pathological studies and in CI by in vivo magnetic resonance spectroscopy, yet GM pathology is subtle and difficult to detect using conventional T1- and T2-weighted magnetic resonance imaging (MRI). There is a need for high-resolution, clinically accessible imaging techniques that probe molecular changes in GM. Objective: To study cortical GM pathology related to CI in MS using glutamate-sensitive chemical exchange saturation transfer (GluCEST) MRI at 7.0 Tesla (7T). Methods: A total of 20 patients with relapsing-remitting MS and 20 healthy controls underwent cognitive testing, anatomical imaging, and GluCEST imaging. Glutamate-sensitive image contrast was quantified for cortical GM, compared between cohorts, and correlated with clinical measures of CI. Results and Conclusion: Glutamate-sensitive contrast was significantly increased in the prefrontal cortex of MS patients with accumulated disability ( p S = −0.814) and choice reaction time ( rS = 0.772) scores in patients ( p |
| Databáze: | OpenAIRE |
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