Peripheral neuropathy in ANCA-associated vasculitis: outcomes from the European Vasculitis Study Group trials
| Autor: | Suppiah, R, Hadden, RDM, Batra, R, Arden, NK, Collins, MP, Guillevin, L, Jayne, DRW, Luqmani, RA, Grp, EVS |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Gastroenterology chemistry.chemical_compound Rheumatology Internal medicine medicine Prevalence Humans Pharmacology (medical) Aged Creatinine Clinical Trials as Topic business.industry Incidence (epidemiology) Incidence Hazard ratio Peripheral Nervous System Diseases Odds ratio Middle Aged medicine.disease Surgery Europe Peripheral neuropathy Treatment Outcome chemistry Chronic Disease Female Vasculitis business Granulomatosis with polyangiitis Microscopic polyangiitis |
| Zdroj: | Rheumatology (Oxford, England). 50(12) |
| ISSN: | 1462-0332 |
| Popis: | OBJECTIVES: To describe the incidence and prevalence of peripheral neuropathy in ANCA-associated vasculitis (AAV); to evaluate the correlation of neuropathy with other clinical manifestations; and to review the long-term outcome of treated neuropathy. METHODS: Presence of neuropathy was determined using items from the BVAS and vasculitis damage index (VDI) during 5 years from enrollment into clinical trials conducted by the European Vasculitis Study Group (EUVAS). RESULTS: Forty (8%) of 506 patients had vasculitic neuropathy at baseline. Incidence of vasculitic motor-involving neuropathy was identical between microscopic polyangiitis (MPA) [16 (7%) out of 237] and granulomatosis with polyangiitis (Wegener's) [19 (7%) out of 269], P = 0.94. Pure sensory neuropathy was reported in 5 (2%) out of 269 patients with granulomatosis with polyangiitis, but not in patients with MPA, P = 0.065. Vasculitic neuropathy at baseline was associated with systemic [odds ratio (OR) = 1.81], cutaneous (OR = 1.29), mucous membranes (OR = 1.21) and ENT (OR = 1.14) manifestations of vasculitis (P |
| Databáze: | OpenAIRE |
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