A new cytotoxic coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl] oxy coumarin, from the leaves of Zanthoxylum schinifolium
| Autor: | Young Ho Kim, Eun Sook Ma, Dong Geol Hyun, Su Yang Jeong, Mi Hee Woo, Bo Kyung Min |
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| Rok vydání: | 2010 |
| Předmět: |
Zanthoxylum
Leukemia T-Cell Magnetic Resonance Spectroscopy Stereochemistry Cell Survival Jurkat cells Chloride Mass Spectrometry chemistry.chemical_compound Inhibitory Concentration 50 Jurkat Cells Isomerism Coumarins Drug Discovery Republic of Korea Spectroscopy Fourier Transform Infrared medicine Humans heterocyclic compounds Methylene Cytotoxicity IC50 Chromatography High Pressure Liquid Methylene Chloride Molecular Structure Plant Extracts Organic Chemistry Coumarin Antineoplastic Agents Phytogenic Plant Leaves chemistry Auraptene Solvents Molecular Medicine Zanthoxylum schinifolium medicine.drug |
| Zdroj: | Archives of pharmacal research. 34(5) |
| ISSN: | 1976-3786 |
| Popis: | A new coumarin, 7-[(E)-3',7'-dimethyl-6'-oxo-2',7'-octadienyl]oxy coumarin (1), together with three known compounds, schinilenol (2), schinindiol (3) and 7-[(E)-7'-hydroxy-3',7'-dimethylocta-2',5'-dienyloxy]-coumarin (4) were isolated from the methylene chloride fraction of Z. schinifolium by normal and reverse phase column chromatographies. Their structures were determined on the basis of physical and spectroscopic evidences. Compound 1 (IC(50) 8.10 μM) showed potent cytotoxicity compared to auraptene (IC(50) 55.36 μM) against Jurkat T cells. The other isolated compounds 2 and 4 exhibited weak cytotoxicities. |
| Databáze: | OpenAIRE |
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