Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development
| Autor: | Fabrice Chatonnet, Nicolas Fossat, Thomas Lamonerie, Frederic Picou, Frédéric Flamant, Sabine Richard, Teddy Fauquier, Nadine Aguilera |
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| Přispěvatelé: | BioSciences Lyon-Gerland (BLG), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), EU CRESCENDO Integrated project [LSHM-CT-2005-018652], Agence Nationale pour la Recherche, École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon |
| Rok vydání: | 2013 |
| Předmět: |
Cerebellum
Mouse PAX6 Transcription Factor MESH: Triiodothyronine Mice Purkinje Cells 0302 clinical medicine MESH: Eye Proteins Cell Movement Paired Box Transcription Factors MESH: Animals Receptor MESH: Cell Movement [SDV.BDD]Life Sciences [q-bio]/Development Biology Thyroid hormone receptor 0303 health sciences Thyroid Cell Differentiation medicine.anatomical_structure MESH: Repressor Proteins Triiodothyronine MESH: Neuroglia Neuroglia Thyroid Hormone Receptors alpha MESH: Cell Differentiation medicine.medical_specialty Cell type Central nervous system MESH: Thyroid Hormone Receptors alpha Biology 03 medical and health sciences MESH: Purkinje Cells MESH: Mice Inbred C57BL MESH: Cell Proliferation Internal medicine MESH: Homeodomain Proteins medicine Animals MESH: Paired Box Transcription Factors Eye Proteins MESH: Mice Molecular Biology 030304 developmental biology Cell Proliferation Homeodomain Proteins Granule cell MESH: Cerebellum Mice Inbred C57BL Repressor Proteins Endocrinology nervous system 030217 neurology & neurosurgery Developmental Biology Hormone |
| Zdroj: | Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2013, 141 (1), pp.166-175. ⟨10.1242/dev.103226⟩ Development (Cambridge, England), Company of Biologists, 2014, 141 (1), pp.166-75. ⟨10.1242/dev.103226⟩ |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.103226⟩ |
| Popis: | International audience; Thyroid hormone is necessary for normal development of the central nervous system, as shown by the severe mental retardation syndrome affecting hypothyroid patients with low levels of active thyroid hormone. The postnatal defects observed in hypothyroid mouse cerebellum are recapitulated in mice heterozygous for a dominant-negative mutation of Thra, the gene encoding the ubiquitous TRα1 receptor. Using CRE/loxP-mediated conditional expression approach, we found that this mutation primarily alters the differentiation of Purkinje cells and Bergmann glia, two cerebellum-specific cell types. These primary defects indirectly affect cerebellum development in a global manner. Notably, the inward migration and terminal differentiation of granule cell precursors is impaired. Therefore, despite the broad distribution of its receptors, thyroid hormone targets few cell types that exert a predominant role in the network of cellular interactions that govern normal cerebellum maturation. |
| Databáze: | OpenAIRE |
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