Effects of Low Doses of Cyproterone Acetate on Sperm Morphology and some other Parameters of Reproduction in Normal Men
| Autor: | B. Fredricsson, K. Carlström |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Sterility Urology media_common.quotation_subject Motility Semen Biology Andrology chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Testosterone Cyproterone Cyproterone Acetate media_common Azoospermia urogenital system Contraceptive Agents Male Cyproterone acetate Estrogens General Medicine Luteinizing Hormone medicine.disease Spermatozoa Sperm Prolactin chemistry Sperm Motility Follicle Stimulating Hormone Reproduction |
| Zdroj: | Andrologia. 13:369-375 |
| ISSN: | 1439-0272 0303-4569 |
| Popis: | Cyproterone acetate was given to three healthy men in a dosage of 10 mg per day for 8-14 weeks. The effects on sperm count, morphology, motility and vitality was followed weekly and compared with the effects of 25 mg daily in another case. Sperm morphology included the study of live spermatozoa separately. The effects on serum levels of FSH, LH, testosterone and oestrogens was also studied. With respect to sperm count and morphology a dose-effect relationship is indicated. Abnormalities within tails and midpieces of live spermatozoa appear early and may predict sterility before azoospermia develops. FSH and oestrogens were comparatively more depressed than LH and testosterone. The results indicate that cyproterone acetate may have an androgenic (or gestagenic) effect on the hypophyseo-hypothalamic level in addition to an antiandrogenic effect on gonads and their accessory organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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