Barriers to Participation in Therapeutic Clinical Trials as Perceived by Community Oncologists
| Autor: | Jennifer Liu, Kevin George, Brandon A. Chen, Andrew R. Wong, Virginia Sun, Daneng Li, Thomas George, Arya Amini, Simran Padam, Mina S. Sedrak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
MEDLINE ORIGINAL CONTRIBUTIONS 03 medical and health sciences 0302 clinical medicine Neoplasms Physicians medicine Humans 030212 general & internal medicine Oncologists Clinical Trials as Topic Oncology (nursing) business.industry Patient Selection Health Policy Perspective (graphical) Cancer medicine.disease Therapeutic trial Clinical trial Oncology 030220 oncology & carcinogenesis Family medicine Female business |
| Zdroj: | JCO Oncol Pract |
| ISSN: | 2688-1535 2688-1527 |
| Popis: | PURPOSE: Despite considerable research on the barriers to enrollment in cancer therapeutic trials, few studies have elicited barriers from the perspective of community physicians, who provide the majority of cancer care. The purpose of this study was to characterize barriers to and facilitators of cancer therapeutic trials as perceived by oncologists in community practices. METHODS: Twenty semistructured interviews were conducted with oncologists at six community sites affiliated with City of Hope National Medical Center from March to June 2018. Responses were recorded digitally and transcribed. Data were analyzed using qualitative content analysis. RESULTS: Of the 20 participants, 4 (20%) were women, 13 (65%) had > 10 years of practice experience, and 16 (80%) reported that < 5% of their patients were enrolled in a therapeutic trial. Participants identified four system-level barriers: lack of appropriate trials for community-based settings, insufficient infrastructure support, restrictive eligibility criteria, and financial limitations; three physician-level barriers: lack of awareness of available trials, lack of knowledge of trial details, and lack of time; and two patient-level barriers: patient burden and negative beliefs/attitudes toward research. Efforts aimed to increase trial availability, clinical trial support personnel, and physician knowledge were identified as major facilitators. CONCLUSION: Community oncologists face numerous complex, multifaceted barriers to cancer therapeutic trial enrollment. Although expanding clinical research beyond the academic setting allows access to a larger and more diverse patient population, increasing generalizability and relevance of trial findings, there remains a substantial need for new strategies to improve cancer research delivery in the community. |
| Databáze: | OpenAIRE |
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