Statins and gastroduodenal endoscopic lesions
| Autor: | Simona Mocan, Monica Pantea, Anca Negovan, Septimiu Voidazan, Simona Băţagă, Melania Macarie |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Peptic Ulcer low-dose aspirin medicine.medical_specialty MEDLINE Observational Study Prostaglandin Comorbidity 030204 cardiovascular system & hematology comorbidities Gastroenterology Helicobacter Infections 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Text mining Risk Factors Internal medicine Odds Ratio medicine Humans Endogenous nitric oxide Aged Chi-Square Distribution Aspirin Helicobacter pylori business.industry statin Case-control study Endoscopy General Medicine Odds ratio Middle Aged medicine.disease endoscopic lesions Logistic Models chemistry Case-Control Studies Female lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology Hydroxymethylglutaryl-CoA Reductase Inhibitors business Chi-squared distribution Platelet Aggregation Inhibitors Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Experimental studies showed a dose-dependent gastroprotective effect of statins on non-steroidal anti-inflammatory drug-induced endoscopic lesions, modulated by increasing endogenous nitric oxide and prostaglandin production. We investigated the influence of chronic treatment with statins on the occurrence of endoscopic lesions in patients referred for endoscopic evaluation, adjusted for the most important etiologic and risk factors for peptic ulcer disease and its complications. A consecutive series of 564 patients who underwent upper digestive endoscopy, stratified according to the severity of endoscopic lesions were recruited. Patients with statin therapy were included in the study group (n = 220), while patients without statins in the control group (n = 344). We correlate the influence of chronic statin therapy (at least 6 months) with factors including age up to 50 years, Helicobacter pylori infection, smoking and drinking habits, ulcer history, gastrotoxic drug consumption (low-dose aspirin [ASA], anticoagulants), and comorbidities. H pylori infection was more frequent in patients with mild/severe endoscopic lesions vs. no lesions, in both groups, but the difference was not statistically significant (P >.05). Male gender represented a risk factor (P |
| Databáze: | OpenAIRE |
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