Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents

Autor: Jue Sollid, Magnus Wickman, Claus Klingenberg, Jean Bousquet, Martin Sørensen, A-S Furberg, Claus Bachert
Přispěvatelé: Department of Molecular Medicine and Surgery, Karolinska Institutet [Stockholm], Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Allergy
Immunoglobulin E
medicine.disease_cause
Allergic sensitization
Enterotoxins
0302 clinical medicine
Allergen
Odds Ratio
Prevalence
Immunology and Allergy
Medicine
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
Sensitization
education.field_of_study
biology
Age Factors
Atopic dermatitis
3. Good health
medicine.anatomical_structure
Carrier State
Female
Staphylococcus aureus
Adolescent
Immunology
Population
Cross Reactions
03 medical and health sciences
Allergic multimorbidity
Allergic disease
Hypersensitivity
Humans
education
Asthma
Antigens
Bacterial
Staphylococcus aureus Enterotoxins
business.industry
Poly-sensitization
Multimorbidity
Allergens
medicine.disease
030104 developmental biology
Cross-Sectional Studies
030228 respiratory system
biology.protein
Immunization
business
Zdroj: Allergy
Allergy, Wiley, 2017, 72 (10), pp.1548-1555. ⟨10.1111/all.13175⟩
ISSN: 0105-4538
1398-9995
Popis: Background: Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromso Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear. Objective: To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization. Methods: A cross-sectional study of a school-based cohort in late adolescence (aged 18-19 years: The Tromso Study Fit Futures 2). Self-reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens. Results: A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly-sensitization to food and inhalant allergens. SE-sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1-118.4) compared to non-SE-sensitized participants (18.0 kU(A)/L, IQR 5.5-48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity. Conclusion: Sensitization to SEs may play a role in the development of allergen poly-sensitization and allergic multimorbidity.
Databáze: OpenAIRE
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